TY - JOUR
T1 - Extracellular vesicles released from irradiated neonatal mouse cheek tissue increased cell survival after radiation
AU - Ariyoshi, Kentaro
AU - Hiroyama, Yota
AU - Fujiwara, Naoya
AU - Miura, Tomisato
AU - Kasai, Kosuke
AU - Nakata, Akifumi
AU - Fujishima, Yohei
AU - Ting Goh, Valerie Swee
AU - Yoshida, Mitsuaki A.
N1 - Publisher Copyright:
© 2020 The Author(s) 2020. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Alopecia is one of the common symptoms after high-dose radiation exposure. In our experiments, neonatal mice that received 7 Gy X-ray exhibited defects in overall hair growth, except for their cheeks. This phenomenon might suggest that some substances were secreted and prevented hair follicle loss in the infant tissues around their cheeks after radiation damage. In this study, we focused on exosome-like vesicles (ELV) secreted from cheek skin tissues and back skin tissues, as control, and examined their radiation protective effects on mouse fibroblast cell lines. We observed that ELV from irradiated cheek skin showed protective effects from radiation. Our results suggest that ELV from radiation-exposed cheek skin tissue is one of the secreted factors that prevent hair follicle loss after high-dose radiation.
AB - Alopecia is one of the common symptoms after high-dose radiation exposure. In our experiments, neonatal mice that received 7 Gy X-ray exhibited defects in overall hair growth, except for their cheeks. This phenomenon might suggest that some substances were secreted and prevented hair follicle loss in the infant tissues around their cheeks after radiation damage. In this study, we focused on exosome-like vesicles (ELV) secreted from cheek skin tissues and back skin tissues, as control, and examined their radiation protective effects on mouse fibroblast cell lines. We observed that ELV from irradiated cheek skin showed protective effects from radiation. Our results suggest that ELV from radiation-exposed cheek skin tissue is one of the secreted factors that prevent hair follicle loss after high-dose radiation.
KW - animal model
KW - extracellular vesicles
KW - radiation protection
KW - skin tissue
UR - http://www.scopus.com/inward/record.url?scp=85099326678&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85099326678&partnerID=8YFLogxK
U2 - 10.1093/jrr/rraa106
DO - 10.1093/jrr/rraa106
M3 - Article
C2 - 33302296
AN - SCOPUS:85099326678
SN - 0449-3060
VL - 62
SP - 73
EP - 78
JO - Journal of Radiation Research
JF - Journal of Radiation Research
IS - 1
ER -