Fabrication and characterization of biodegradable nano-particles containing a drug for DDS by self-organized precipitation method

Daisuke Ohsato, Masaru Tanaka, Sadaaki Yamamoto, Takeshi Higuchi, Hiroshi Yabu, Masatsugu Shimomura

研究成果: 会議への寄与学会論文査読

抄録

Recently, we have reported the preparation of nano-particles by mixing a poor solvent into a solution of polymer, and evaporating a good solvent. In this report, biodegradable polymer particles containing pyrene (Py) as a model compound of hydrophobic drug were fabricated. The morphology of particles was observed by FE-SEM. The content of Py in the particles was determined as c.a. 10 wt%. By measuring fluorescence spectra, we found that the Py in the particles was distributed in the state of monomer. Py was released about 80% over 200 hours in 10 mM sodium phosphate buffer (pH7.4).

本文言語英語
ページ1948
ページ数1
出版ステータス出版済み - 2006
イベント55th SPSJ Annual Meeting - Nagoya, 日本
継続期間: 2006 5月 242006 5月 26

会議

会議55th SPSJ Annual Meeting
国/地域日本
CityNagoya
Period06/5/2406/5/26

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