抄録
Preparation of peptide thioester is essential for native chemical ligation and block condensation. Our novel methodology involves conversion of the carboxylic acid of a peptide into a thioester using p-toluenesulfonyl isocyanate, followed by alkylation, then thiol substitution. Our methodology can also be used for the preparation of glycopeptide thioesters. Furthermore, it is possible to carry out the reaction as a sequential peptide chemical ligation.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 849-853 |
| ページ数 | 5 |
| ジャーナル | Tetrahedron Letters |
| 巻 | 48 |
| 号 | 5 |
| DOI | |
| 出版ステータス | Published - 2007 1月 29 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 生化学
- 創薬
- 有機化学