High sensitivity and large dynamic range surface plasmon resonance sensing for DNA hybridization using au-nanoparticle-attached probe DNA

Masayuki Hayashida, Akira Yamaguchi, Hiroaki Misawa

研究成果: Article査読

17 被引用数 (Scopus)

抄録

In this study, we demonstrate the use of surface plasmon interaction between Au nanoparticles (GPs) and a Au thin film for enhancement of surface plasmon resonance (SPR) spectroscopy sensing for DNA hybridization. In situ DNA hybridization with a Au-nanoparticle-attached probe DNA (DNA-GP) monolayer is monitored by SPR spectroscopy, and the results reveal that the DNA-GP allows detection of unlabeled target DNA with the large dynamic range of 1 pM to 10 μM.

本文言語English
ジャーナルJapanese Journal of Applied Physics, Part 2: Letters
44
50-52
DOI
出版ステータスPublished - 2005 12月 16

ASJC Scopus subject areas

  • 物理学および天文学(その他)

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