Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents

Shinya Ohara, Märt Rannap, Ken Ichiro Tsutsui, Andreas Draguhn, Alexei V. Egorov, Menno P. Witter

研究成果: Article査読

1 被引用数 (Scopus)


The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing and in vitro electrophysiology data, however, show a markedly different dorsoventral organization of the hippocampal projection to the medial EC (MEC). While dorsal hippocampal projections are confined to the dorsal MEC, ventral hippocampal projections innervate both dorsal and ventral MEC. Further, whereas the dorsal hippocampus preferentially targets layer Vb (LVb) neurons, the ventral hippocampus mainly targets cells in layer Va (LVa). This connectivity scheme differs from hippocampal projections to the lateral EC, which are topographically organized along the dorsoventral axis. As LVa neurons project to telencephalic structures, our findings indicate that the ventral hippocampus regulates LVa-mediated entorhinal-neocortical output from both dorsal and ventral MEC. Overall, the marked dorsoventral differences in hippocampal-entorhinal connectivity impose important constraints on signal flow in hippocampal-neocortical circuits.

ジャーナルCell Reports
出版ステータスPublished - 2023 1月 31

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)


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