TY - JOUR
T1 - Host-Selective Phytotoxins Incorporating the Epoxy-Triene-Decacarboxylate Moiety Function through the Hijacking of the Plant-Microbe Interaction System
AU - Ueda, Minoru
AU - Kato, Nobuki
AU - Kurata, Yoshinori
AU - Imai, Masaki
AU - Yang, Gangqiang
AU - Taniguchi, Keigo
N1 - Funding Information:
We thank Y. Ishimaru (Tohoku University) and T. Tsuge (Chubu University) for their helpful discussion on HST, K. Hayashi (Tohoku University) for the technical assistance, and M. Nagano (Ritsumeikan University) for providing us the seed of the OsrbohB mutant. This work was financially supported by a Grant-in-Aid for Scientific Research from JSPS, Japan (nos. 17H0607, 18KK0162, and 20H00402 for M.U.), a SUNBOR grant (N.K.), the JSPS A3 Foresight Program (M.U.), and the JSPS Core-to-Core Program Asian Chemical Biology Initiative (M.U.).
Publisher Copyright:
© 2022 American Chemical Society.
PY - 2023/1/20
Y1 - 2023/1/20
N2 - Host selective toxins (HSTs) are small molecule phytotoxins that control the pathogenicity of microbes in the host plant, but the mechanistic basis for their selectivity is unknown. We developed AcIle-EDA (Aclle-(+)-9,10-epoxy-8-hydroxy-9-methyldeca-trienoic acid) as a molecular probe of an HST, examined its mode of action in genetically modified Oryza sativa, and found it to trigger ROS production through NADPH-oxidase OsRBOHB, causing the emergence of pathogenic traits. This result strongly suggests that AcIle-EDA functions through the hijacking of the plant-microbe interaction system.
AB - Host selective toxins (HSTs) are small molecule phytotoxins that control the pathogenicity of microbes in the host plant, but the mechanistic basis for their selectivity is unknown. We developed AcIle-EDA (Aclle-(+)-9,10-epoxy-8-hydroxy-9-methyldeca-trienoic acid) as a molecular probe of an HST, examined its mode of action in genetically modified Oryza sativa, and found it to trigger ROS production through NADPH-oxidase OsRBOHB, causing the emergence of pathogenic traits. This result strongly suggests that AcIle-EDA functions through the hijacking of the plant-microbe interaction system.
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U2 - 10.1021/acschembio.2c00777
DO - 10.1021/acschembio.2c00777
M3 - Article
C2 - 36547375
AN - SCOPUS:85144993812
SN - 1554-8929
VL - 18
SP - 12
EP - 17
JO - ACS Chemical Biology
JF - ACS Chemical Biology
IS - 1
ER -