Immuno-wall lab-on-a-chip protein analysis devices for high precision surgery of gliomas

T. Kasama, A. Yamamichi, F. Ohka, Y. Kato, H. Suzuki, A. Kato, K. Motomura, M. Hirano, M. Ranjit, L. Chalise, M. Kurimoto, G. Kondo, K. Aoki, N. Kaji, T. Matsubara, H. Suzuki, M. Tokeshi, T. Wakabayashi, A. Natsume, Y. Baba

研究成果: 書籍の章/レポート/Proceedings会議への寄与査読

抄録

In the present study, we propose immuno-wall lab-on-a-chip protein analysis devices for ultrarapid detection of R132H mutant isocitrate dehydrogenase 1 (IDH1) that we identified as a specifically and commonly expressed gene in diffusely infiltrative gliomas1. In 9 min immunoassay, we successfully carried out specific detection of R132H mutant IDH1 in a lysate of glioma tissue, which is much faster than intraoperative pathological diagnosis. Moreover, clinical samples from 10 patients with gliomas were analyzed by using the immuno-wall devices. These results were consistent with those of PCR-based genetic mutation detection method. Our devices realize point-of-care tumor testing, resulting in the high precision surgery of gliomas.

本文言語英語
ホスト出版物のタイトル20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
出版社Chemical and Biological Microsystems Society
ページ651-652
ページ数2
ISBN(電子版)9780979806490
出版ステータス出版済み - 2016
イベント20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, アイルランド
継続期間: 2016 10月 92016 10月 13

出版物シリーズ

名前20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

会議

会議20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
国/地域アイルランド
CityDublin
Period16/10/916/10/13

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