Impact of sleep-disordered breathing on glucose metabolism among individuals with a family history of diabetes: The Nagahama study

Study Objectives: It is well known that a family history of diabetes (FHD) is a definitive risk factor for type 2 diabetes. It has not been known whether sleepdisordered breathing (SDB) increases the prevalence of diabetes in those with an FHD. Methods: We assessed SDB severity in 7, 477 study participants by oximetry corrected by objective sleep duration determined by wrist actigraphy. Glycated hemoglobin ≥6.5% and/or current medication for diabetes indicated the presence of diabetes. In addition to the overall prevalence, the prevalence of recent-onset diabetes during the nearly 5 years before the SDB measurements were made was investigated. Results: Of the 7, 477 participants (mean age: 57.9; range: 34.2-80.7; SD: 12.1 years; 67.7% females), 1, 569 had an FHD. The prevalence of diabetes in FHD participants with moderate-to-severe SDB (MS-SDB) was higher than in those without SDB (MS-SDB vs without SDB: all, 29.3% vs 3.3% [P <.001]; females, 32.6% vs 1.9% [P <.001];males, 26.2%vs 11.7%[P =.037]). However, multivariate analysis showed thatMS-SDB was significantly associated with a higher prevalence of diabetes only in FHD-positive females (odds ratio [95% confidence interval]: females, 7.43 [3.16-17.45]; males, 0.92 [0.37-2.31]). Among the FHD-positive participants, the prevalence of recent-onset diabetes was higher in those with MS-SDB than thosewithout SDB, but only in females (MS-SDB vs without SDB: 21.4% vs 1.1%; P < 0.001). Conclusions:MS-SDB was associated with diabetes risk in females with an FHD, and future studies are needed on whether treatment of SDB in females with an FHD would prevent the onset of diabetes.