TY - GEN
T1 - Influence of nanostructure on proliferation and differentiation processes of stem cell
AU - Kubo, Kazutoshi
AU - Okamoto, Yukihiro
AU - Yamamoto, Masaya
AU - Kaji, Noritada
AU - Tokeshi, Manabu
AU - Tabata, Yasuhiko
AU - Baba, Yoshinobu
PY - 2010
Y1 - 2010
N2 - In this work, we used nanometer sized grooves which fabricated by nano imprinting method combined with a sol-gel process and observed the effect of nanostructure on mesenchymal stem cells (MSCs). MSCs on the nanostructures spread along the grooves in the first stage of proliferation, and then aggregated after differentiation to osteoblasts. In addition, the proliferation rate of MSCs on the nanostructures was suppressed compared to that on the flat surfaces. These results indicate that nanostructures change the environment around MSCs and affect the behavior of MSCs.
AB - In this work, we used nanometer sized grooves which fabricated by nano imprinting method combined with a sol-gel process and observed the effect of nanostructure on mesenchymal stem cells (MSCs). MSCs on the nanostructures spread along the grooves in the first stage of proliferation, and then aggregated after differentiation to osteoblasts. In addition, the proliferation rate of MSCs on the nanostructures was suppressed compared to that on the flat surfaces. These results indicate that nanostructures change the environment around MSCs and affect the behavior of MSCs.
KW - Cell behavior
KW - Cell differentiation
KW - Mesenchymal stem cells
KW - Nanostructure
UR - http://www.scopus.com/inward/record.url?scp=84884323312&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884323312&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84884323312
SN - 9781618390622
T3 - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
SP - 181
EP - 183
BT - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
T2 - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Y2 - 3 October 2010 through 7 October 2010
ER -