@article{a0e2339d1ce647c9bafa2f456a153eaa,
title = "Inverse correlation between Flt3 and PU.1 expression in acute myeloblastic leukemias",
abstract = "Over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), playing a role in leukemogenesis while decreased expression of PU.1 induces AML in mice model. Therefore, we speculated that there is an inverse relationship between these two factors. To clarify this, we measured the expression level of Flt3 and PU.1 in 24 primary AML specimens. As a result, there is a significant negative correlation between Flt3 and PU.1 (r = -0.43, p < 0.05). Furthermore, we revealed that flt3 gene promoter is suppressed by the over-expression of PU.1, suggesting that PU.1 is a potential suppressor of flt3 gene promoter.",
keywords = "AML, Flt3, PU.1",
author = "Mitsue Inomata and Shinichiro Takahashi and Hideo Harigae and Junichi Kameoka and Mitsuo Kaku and Takeshi Sasaki",
note = "Funding Information: Authors thank for Dr. I. Ishikawa at Furukawa City Hospital and all the members in Department of Rheumatology and Hematology for helping collecting AML specimens. This work is supported in part by the Kurozumi Medical Foundation (to S.T.), MEXT.KAKENHI (17790635) (to S.T.) and Grant-in Aid from Japan Society for the Promotion of Science (to H.H. and T.S.). ",
year = "2006",
month = jun,
doi = "10.1016/j.leukres.2005.07.015",
language = "English",
volume = "30",
pages = "659--664",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Ltd.",
number = "6",
}
