Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol-Induced Liver Damage

Jeremy P. Koelmel, Wan Y. Tan, Yang Li, John A. Bowden, Atiye Ahmadireskety, Andrew C. Patt, David J. Orlicky, Ewy Mathé, Nicholas M. Kroeger, David C. Thompson, Jason A. Cochran, Jaya Prakash Golla, Aikaterini Kandyliari, Ying Chen, Georgia Charkoftaki, Joy D. Guingab-Cagmat, Hiroshi Tsugawa, Anmol Arora, Kirill Veselkov, Shunji KatoYurika Otoki, Kiyotaka Nakagawa, Richard A. Yost, Timothy J. Garrett, Vasilis Vasiliou

    研究成果: Article査読

    4 被引用数 (Scopus)


    Alcoholic fatty liver disease (AFLD) is characterized by lipid accumulation and inflammation and can progress to cirrhosis and cancer in the liver. AFLD diagnosis currently relies on histological analysis of liver biopsies. Early detection permits interventions that would prevent progression to cirrhosis or later stages of the disease. Herein, we have conducted the first comprehensive time-course study of lipids using novel state-of-the art lipidomics methods in plasma and liver in the early stages of a mouse model of AFLD, i.e., Lieber-DeCarli diet model. In ethanol-treated mice, changes in liver tissue included up-regulation of triglycerides (TGs) and oxidized TGs and down-regulation of phosphatidylcholine, lysophosphatidylcholine, and 20-22-carbon-containing lipid-mediator precursors. An increase in oxidized TGs preceded histological signs of early AFLD, i.e., steatosis, with these changes observed in both the liver and plasma. The major lipid classes dysregulated by ethanol play important roles in hepatic inflammation, steatosis, and oxidative damage. Conclusion: Alcohol consumption alters the liver lipidome before overt histological markers of early AFLD. This introduces the exciting possibility that specific lipids may serve as earlier biomarkers of AFLD than those currently being used.

    ジャーナルHepatology Communications
    出版ステータスPublished - 2022 3月

    ASJC Scopus subject areas

    • 肝臓学


    「Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol-Induced Liver Damage」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。