M cell-depletion blocks oral prion disease pathogenesis

D. S. Donaldson, A. Kobayashi, H. Ohno, H. Yagita, I. R. Williams, N. A. Mabbott

研究成果: Article査読

70 被引用数 (Scopus)


Many prion diseases are orally acquired. Our data show that after oral exposure, early prion replication upon follicular dendritic cells (FDC) in Peyer's patches is obligatory for the efficient spread of disease to the brain (termed neuroinvasion). For prions to replicate on FDC within Peyer's patches after ingestion of a contaminated meal, they must first cross the gut epithelium. However, the mechanism through which prions are conveyed into Peyer's patches is uncertain. Within the follicle-associated epithelium overlying Peyer's patches are microfold cells (M cells), unique epithelial cells specialized for the transcytosis of particles. We show that following M cell-depletion, early prion accumulation upon FDC in Peyer's patches is blocked. Furthermore, in the absence of M cells at the time of oral exposure, neuroinvasion and disease development are likewise blocked. These data suggest M cells are important sites of prion uptake from the gut lumen into Peyer's patches. 2012 Society for Mucosal Immunology.

ジャーナルMucosal Immunology
出版ステータスPublished - 2012 3月

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学


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