Marked improvement of delayed methotrexate-induced leukoencephalopathy treated with high-dose folinic acid

研究成果: ジャーナルへの寄稿学術論文査読

抄録

We report the case of a patient with delayed methotrexate (MTX)-induced leukoencephalopathy who showed a marked improvement both in clinical and neuroimaging findings after a high-dose of the active form of folinic acid (leucovorin) treatment. The patient developed progressive affective impairment accompanied by headache, nausea and vomiting after treatment with MTX during the chemotherapy for acute lymphoblastic leukemia, and diagnosed as delayed type MTX-induced leukoencephalopathy. After an intravenous injection of high-dose folinic acid (total 1920 mg), neurological deficits and white matter changes dramatically improved in a few weeks. Although delayed MTX-induced leukoencephalopathy may cause irreversible brain damage, an early treatment with high dose leucovorin may thus facilitate the marked improvement of clinical findings and white matter abnormalities.

本文言語英語
ページ(範囲)517-520
ページ数4
ジャーナルEuropean Journal of Neurology
4
5
DOI
出版ステータス出版済み - 1997

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