TY - GEN
T1 - Microscale flow dynamics of red blood cells in microchannels
T2 - 1st ECCOMAS Thematic Conference on Computational Vision and Medical Image processing, VIPimage 2007
AU - Lima, R.
AU - Nakamura, M.
AU - Omori, T.
AU - Ishikawa, T.
AU - Wada, S.
AU - Yamaguchi, T.
N1 - Funding Information:
This study was supported in part by the following grants: International Doctoral Program in Engineering from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT), "Revolutionary Simulation Software (RSS21)" next-generation IT program of MEXT; Grants-in-Aid for Scientific Research from MEXT and JSPS Scientific Research in Priority Areas (768) "Biomechanics at Micro- and Nanoscale Levels, Scientific Research (S) No. 19100008, Grant-in-Aid for Young Scientists (A) 19680024.
Publisher Copyright:
© Springer Science+Business Media B.V. 2009.
PY - 2009
Y1 - 2009
N2 - The blood flow dynamics in microcirculation depends strongly on the motion, deformation and interaction of red blood cells (RBCs) within the microvessel. We present confocal micro-PTV measurements on the motion of individual RBCs through a circular polydimethysiloxane (PDMS) microchannel. The RBC radial displacement and dispersion calculated from these measurements show that the RBC paths are strongly dependent on the both Hct and plasma layer. In order to obtain more detailed information of the non-Newtonian property of blood a novel computational scheme is also described. The simulated flow dynamics were in good agreement with the Casson flow model and in vivo observations. In the near future by comparing both results we hope to clarify a variety of complex phenomena occurring at the microscale level.
AB - The blood flow dynamics in microcirculation depends strongly on the motion, deformation and interaction of red blood cells (RBCs) within the microvessel. We present confocal micro-PTV measurements on the motion of individual RBCs through a circular polydimethysiloxane (PDMS) microchannel. The RBC radial displacement and dispersion calculated from these measurements show that the RBC paths are strongly dependent on the both Hct and plasma layer. In order to obtain more detailed information of the non-Newtonian property of blood a novel computational scheme is also described. The simulated flow dynamics were in good agreement with the Casson flow model and in vivo observations. In the near future by comparing both results we hope to clarify a variety of complex phenomena occurring at the microscale level.
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U2 - 10.1007/978-1-4020-9086-8_12
DO - 10.1007/978-1-4020-9086-8_12
M3 - Conference contribution
AN - SCOPUS:84962798359
SN - 9781402090851
T3 - Computational Methods in Applied Sciences
SP - 203
EP - 220
BT - Advances in Computational Vision and Medical Image Processing
A2 - Manuel, Joao
A2 - Tavares, R.S.
A2 - Jorge, R.M. Natal
PB - Springer
Y2 - 17 October 2007 through 19 October 2007
ER -