抄録
A continuous-flow synthesis of (-)-oseltamivir composed of five flow units was accomplished. In each unit, the following reactions proceed efficiently: (1) a diphenylprolinol silyl ether mediated Michael reaction, (2) a domino reaction of Michael and intermolecular Horner-Wadsworth-Emmons reactions, (3) protonation, (4) epimerization, and (5) reduction of a nitro group to an amine. (-)-Oseltamivir was obtained in 13% total yield through a single flow with a residence time of 310 minutes.
| 本文言語 | English |
|---|---|
| 論文番号 | ss-2016-z0587-op |
| ページ（範囲） | 424-428 |
| ページ数 | 5 |
| ジャーナル | Synthesis (Germany) |
| 巻 | 49 |
| 号 | 2 |
| DOI | |
| 出版ステータス | Published - 2017 1月 18 |
ASJC Scopus subject areas
- 触媒
- 有機化学