N-Acetylcysteine Inhibits Loss of Diaphragm Function in Streptozotocin-treated Rats

Wataru Hida, Chiyohiko Shindoh, J. O. Satoh, Mikio Sagara, Yoshihiro Kikuchi, Takayoshi Toyota, Kunio Shirato

研究成果: Article査読

42 被引用数 (Scopus)


We examined whether streptozotocin (STZ)-induced diabetic rats have an impairment in diaphragm contractility, and if so, whether N-acetylcysteine (NAC), a nonspecific antioxidant, prevents this impairment. First,diaphragm contractility, assessed by tension-frequency relationships and twitch kinetics in in vitro diaphragm strip preparations of Wistar rats, was obtained on Days 3 and 7 after administration of STZ of 30 or 60 mg/kg body weight, and compared with that of the control group. Second, NAC at 500 mg/kg body weight or vehicle solution was administered orally every day in rats treated with STZ at 60 mg/kg body weight, and diaphragm function on Day 7 after starting NAC treatment was compared between vehicle control and STZ-treated groups. We found that diaphragm function in STZ-treated rats, which had hyperglycemia, decreased in a dose-and time-dependent manner. NAC inhibited the decrease in diaphragm contractility in STZ-treated rats without reducing blood glucose. These findings suggest that the loss of diaphragm function in STZ-induced diabetic rats is not directly related to hyperglycemia. The data are consistent with secondary alterations of normal cytokine signaling or changes in the redox state of the cell, both of which could be affected by NAC treatment.

ジャーナルAmerican journal of respiratory and critical care medicine
6 I
出版ステータスPublished - 1996

ASJC Scopus subject areas

  • 呼吸器内科
  • 集中医療医学


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