@article{85781843282a4c67a30e0edc38ddd46c,
title = "Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists",
abstract = "Novel dipeptidyl peptidase IV (DPP-IV) inhibitors with a phenethylphenylphthalimide skeleton were prepared based on α-glucosidase inhibitors and liver X receptor (LXR) antagonists derived from thalidomide. Representative compounds showed non-competitive inhibition of DPP-IV and 28a exhibited 10-fold selectivity for DPP-IV over DPP-8. Compound 28a is the first non-competitive, selective DPP-IV inhibitor.",
keywords = "Dipeptidyl peptidase IV, Enzyme inhibitor, Non-competitive inhibition, Phthalimide, Subtype selectivity",
author = "Kazunori Motoshima and Kazuyuki Sugita and Yuichi Hashimoto and Minoru Ishikawa",
note = "Funding Information: The work described in this paper was partially supported by Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology , Japan, and the Japan Society for the Promotion of Science . ",
year = "2011",
month = may,
day = "15",
doi = "10.1016/j.bmcl.2011.03.026",
language = "English",
volume = "21",
pages = "3041--3045",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "10",
}