TY - JOUR
T1 - Novel synthesis of yttrium phosphate microspheres for radioembolization of cancer
AU - Kawashita, M.
AU - Matsui, N.
AU - Li, Z.
AU - Miyazaki, T.
PY - 2011
Y1 - 2011
N2 - Chemically durable microspheres containing yttrium and/or phosphorus are useful for intra-arterial radiotherapy. In the present study, we attempted to prepare yttrium phosphate (YPO4) microspheres with high chemical durability as well as smooth surface and investigated their chemical durability in simulated body environment. YPO4 microspheres with smooth surface around 25 μm were successfully obtained, when gelatin droplets containing YPO4 precursor was cooled to be solidified in water-in-oil emulsion and then heat-treated at 1100°C. The chemical durability of the heat-treated microspheres in simulated body fluid at pH =6 and 7 was high enough for clinical application of radioembolic therapy of cancer.
AB - Chemically durable microspheres containing yttrium and/or phosphorus are useful for intra-arterial radiotherapy. In the present study, we attempted to prepare yttrium phosphate (YPO4) microspheres with high chemical durability as well as smooth surface and investigated their chemical durability in simulated body environment. YPO4 microspheres with smooth surface around 25 μm were successfully obtained, when gelatin droplets containing YPO4 precursor was cooled to be solidified in water-in-oil emulsion and then heat-treated at 1100°C. The chemical durability of the heat-treated microspheres in simulated body fluid at pH =6 and 7 was high enough for clinical application of radioembolic therapy of cancer.
UR - http://www.scopus.com/inward/record.url?scp=80052081186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052081186&partnerID=8YFLogxK
U2 - 10.1088/1757-899X/18/19/192003
DO - 10.1088/1757-899X/18/19/192003
M3 - Conference article
AN - SCOPUS:80052081186
SN - 1757-8981
VL - 18
JO - IOP Conference Series: Materials Science and Engineering
JF - IOP Conference Series: Materials Science and Engineering
IS - SYMPOSIUM 13
M1 - 192003
T2 - 3rd International Congress on Ceramics, ICC3
Y2 - 14 November 2010 through 18 November 2010
ER -
