@article{4965bc825058410ca8ba50b774c2092f,
title = "Nullscript inhibits Cryptosporidium and Toxoplasma growth",
abstract = "Cryptosporidium and Toxoplasma are parasites that have caused problems worldwide. Cryptosporidium causes severe watery diarrhoea and may be fatal in immunocompromised patients and in infants. Nitazoxanide is the only agent currently approved by the FDA, but its efficacy is limited. Toxoplasmosis is also a problem in the immunocompromised, as currently available treatment options have limited efficacy and patient tolerance can be poor. In the present investigation, we screened libraries of epigenetic compounds to identify those that inhibited C. parvum growth. Nullscript was identified as a compound with an inhibitory effect on C. parvum and T. gondii growth, and was less toxic to host cells. Nullscript was also able to significantly decrease oocyst excretion in C. parvum-infected SCID mice.",
keywords = "Cryptosporidium, HDAC inhibitor, Nullscript, Toxoplasma",
author = "Fumi Murakoshi and Hironori Bando and Tatsuki Sugi and Adeyemi, {Oluyomi Stephen} and Motohiro Nonaka and Takaaki Nakaya and Kentaro Kato",
note = "Funding Information: We thank the Cancer Research Institute of Kanazawa University (Ishikawa, Japan) for providing the chemical library. We also thank Takeshi Yaoi (Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine) for valuable suggestions regarding cell analysis using the IN Cell Analyzer 2200. This study was funded by grants-in-aid for Scientific Research (B) and (C), Scientific Research on Innovative Areas (3805) and Young Scientists (B) from the Ministry of Education, Culture, Science, Sports, and Technology (MEXT) of Japan; and by the Livestock Promotional Subsidy from the Japan Racing Association. Funding Information: We thank the Cancer Research Institute of Kanazawa University (Ishikawa, Japan) for providing the chemical library. We also thank Takeshi Yaoi (Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine) for valuable suggestions regarding cell analysis using the IN Cell Analyzer 2200. This study was funded by grants-in-aid for Scientific Research (B) and (C), Scientific Research on Innovative Areas ( 3805 ) and Young Scientists (B) from the Ministry of Education, Culture, Science, Sports, and Technology (MEXT) of Japan; and by the Livestock Promotional Subsidy from the Japan Racing Association . Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = dec,
doi = "10.1016/j.ijpddr.2020.10.004",
language = "English",
volume = "14",
pages = "159--166",
journal = "International Journal for Parasitology: Drugs and Drug Resistance",
issn = "2211-3207",
publisher = "Elsevier BV",
}
