Orexin-A expression in human peripheral tissues

Masao Nakabayashi, Takashi Suzuki, Kazuhiro Takahashi, Kazuhito Totsune, Yasunari Muramatsu, Chika Kaneko, Fumiko Date, Junji Takeyama, Andrew D. Darnel, Takuya Moriya, Hironobu Sasano

研究成果: Article査読

146 被引用数 (Scopus)


Orexin-A is a neuropeptide present in the brain and is known to regulate feeding and sleeping. In this study, we examined the systemic distribution of orexin-A in human tissues. Immunoreactivity for orexin-A was detected in ganglion cells of the thoracic sympathetic trunk, myenteric plexuses and endocrine cells of the gastrointestinal tract, islet cells of the pancreas and syncytiotrophoblasts and decidual cells of the placenta. In the gastrointestinal tract, orexin-A immunoreactivity was detected in the myenteric plexuses from 26 gestational weeks to birth. In double immunostaining in the pancreas, a great majority of insulin-positive cells was simultaneously positive for orexin-A. mRNA expression for prepro-orexin was also detected in the kidney, adrenal gland, pancreas, placenta, stomach, ileum, colon and colorectal epithelial cells. These results suggest the production of orexin-A in various human peripheral tissues and orexin-A may also play important roles in some peripheral organs.

ジャーナルMolecular and Cellular Endocrinology
出版ステータスPublished - 2003 7月 31

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 内分泌学


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