Organic-base-catalyzed synthesis of phthalides via highly regioselective intramolecular cyclization reaction

Chikashi Kanazawa; Masahiro Terada

doi:10.1016/j.tetlet.2006.12.015

Organic-base-catalyzed synthesis of phthalides via highly regioselective intramolecular cyclization reaction

Chikashi Kanazawa, Masahiro Terada

理学研究科・化学専攻

研究成果: Article › 査読

80 被引用数 (Scopus)

抄録

The organic-base-catalyzed 5-exo intramolecular cyclization reaction of o-alkynylbenzoic acid produces the corresponding phthalide regioselectively in good to excellent yields. The method provides a practical access to the phthalides, an important class of biologically active molecules.

本文言語	English
ページ（範囲）	933-935
ページ数	3
ジャーナル	Tetrahedron Letters
巻	48
号	6
DOI	https://doi.org/10.1016/j.tetlet.2006.12.015
出版ステータス	Published - 2007 2月 5

ASJC Scopus subject areas

生化学
有機化学
創薬

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10.1016/j.tetlet.2006.12.015

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title = "Organic-base-catalyzed synthesis of phthalides via highly regioselective intramolecular cyclization reaction",

abstract = "The organic-base-catalyzed 5-exo intramolecular cyclization reaction of o-alkynylbenzoic acid produces the corresponding phthalide regioselectively in good to excellent yields. The method provides a practical access to the phthalides, an important class of biologically active molecules.",

keywords = "Intramolecular cyclization, Organic-base, Phthalide, Regioselective",

author = "Chikashi Kanazawa and Masahiro Terada",

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AU - Terada, Masahiro

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N2 - The organic-base-catalyzed 5-exo intramolecular cyclization reaction of o-alkynylbenzoic acid produces the corresponding phthalide regioselectively in good to excellent yields. The method provides a practical access to the phthalides, an important class of biologically active molecules.

AB - The organic-base-catalyzed 5-exo intramolecular cyclization reaction of o-alkynylbenzoic acid produces the corresponding phthalide regioselectively in good to excellent yields. The method provides a practical access to the phthalides, an important class of biologically active molecules.

KW - Intramolecular cyclization

KW - Organic-base

KW - Phthalide

KW - Regioselective

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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Organic-base-catalyzed synthesis of phthalides via highly regioselective intramolecular cyclization reaction

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