Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia

Takayuki Yukawa, Yuriko Iwakura, Nobuyuki Takei, Mami Saito, Yuichiro Watanabe, Kazuhiko Toyooka, Michihiro Igarashi, Kazuhiro Niizato, Kenichi Oshima, Yasuto Kunii, Hirooki Yabe, Junya Matsumoto, Akira Wada, Mizuki Hino, Shuji Iritani, Shin ichi Niwa, Ryoko Takeuchi, Hitoshi Takahashi, Akiyoshi Kakita, Toshiyuki SomeyaHiroyuki Nawa

研究成果: ジャーナルへの寄稿学術論文査読

10 被引用数 (Scopus)

抄録

Perineuronal nets comprise chondroitin sulfate moieties and their core proteins, and their neuropathological alterations have been implicated in schizophrenia. To explore the molecular mechanism of the perineuronal net impairments in schizophrenia, we measured the immunoreactivity of chondroitin sulfate moieties, major components of perineuronal nets, in three brain regions (postmortem dorsolateral prefrontal cortex, caudate nucleus, and hippocampus) of schizophrenia patients and control subjects. Immunoblotting for chondroitin 4-sulfate and chondroitin 6-sulfate moieties revealed a significant increase in intensity of a 180 kD band of chondroitin 4-sulfate immunoreactivity in the hippocampus of patients, although we detected no significant alteration in their immunoreactivities with any other molecular sizes or in other brain regions. The levels of immunoreactivity were not correlated with postmortem interval, age, or storage time. We failed to find such an increase in a similar molecular range of the chondroitin 4-sulfate immunoreactivity in the hippocampus of the rats chronically treated with haloperidol. These results suggest that the level alteration of the chondroitin 4-sulfate moiety might contribute to the perineuronal net abnormality found in patients with schizophrenia.

本文言語英語
ページ(範囲)940-946
ページ数7
ジャーナルPsychiatry Research
270
DOI
出版ステータス出版済み - 2018 12月

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