Phase-contrast X-ray computed tomography for observing biological soft tissues

Atsushi Momose, Tohoru Takeda, Yuji Itai, Keiichi Hirako

研究成果: Article査読

750 被引用数 (Scopus)


Biological soft tissues are almost transparent to hard X rays and therefore cannot be investigated without enhancement with a contrast medium, such as iodine. On the other hand, phase-contrast X-ray imaging is sensitive to light elements. This is because the X-ray phase shift cross section is almost a thousand times larger than the X-ray absorption cross section for light elements such as hydrogen, carbon, nitrogen and oxygen. Hence, phase- contrast X-ray imaging is a promising technique for observing the structure inside biological soft tissues without the need for staining and without serious radiation exposure. We have devised a means of observing biological tissues. In three dimensions using a novel X-ray computed tomography (CT) by modifying the phase-contrast technique. To generate appropriate CT input data, we used phase-mapping images obtained using an X-ray interferometer and computer analysis of interference patterns. Now, we present a three- dimensional observation result of a nonstained sample of a cancerous rabbit liver, using a synchrotron X-ray source. Phase-contrast X-ray CT was able to clearly differentiate the cancer lesion from the normal tissue. Moreover, fine structures corresponding to cancerous degeneration and fibrous tissues were clearly depicted.

ジャーナルNature Medicine
出版ステータスPublished - 1996

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)


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