TY - JOUR
T1 - Platelet factor 4 blocks the binding of basic fibroblast growth factor to the receptor and inhibits the spontaneous migration of vascular endothelial cells
AU - Sato, Yasufumi
AU - Abe, Mayumi
AU - Takaki, Ryosaburo
PY - 1990/10/30
Y1 - 1990/10/30
N2 - Platelet factor 4 (PF-4) blocked the binding of basic fibroblast growth factor (bFGF) to the plasma membrane receptor. Five μg/ml of PF-4 completely blocked the specific binding of bFGF to the receptor of NIH 3T3 cells. Endogenously produced bFGF regulates the spontaneous migration of bovine aortic endothelial (BAE) cells as an autocrine factor (Sato and Rifkin, 1988). PF-4 inhibited the spontaneous migration of BAE cells in a reversible and dose dependent manner. The inhibition reached maximum at 5 μg/ml of PF-4, where the binding of bFGF to the receptor was completely blocked.
AB - Platelet factor 4 (PF-4) blocked the binding of basic fibroblast growth factor (bFGF) to the plasma membrane receptor. Five μg/ml of PF-4 completely blocked the specific binding of bFGF to the receptor of NIH 3T3 cells. Endogenously produced bFGF regulates the spontaneous migration of bovine aortic endothelial (BAE) cells as an autocrine factor (Sato and Rifkin, 1988). PF-4 inhibited the spontaneous migration of BAE cells in a reversible and dose dependent manner. The inhibition reached maximum at 5 μg/ml of PF-4, where the binding of bFGF to the receptor was completely blocked.
UR - http://www.scopus.com/inward/record.url?scp=0025109549&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025109549&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(90)90715-Y
DO - 10.1016/0006-291X(90)90715-Y
M3 - Article
C2 - 2173572
AN - SCOPUS:0025109549
SN - 0006-291X
VL - 172
SP - 595
EP - 600
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -