TY - JOUR
T1 - Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors
AU - Ito, Tetsuhide
AU - Tanaka, Masao
AU - Sasano, Hironobu
AU - Osamura, Yoshiyuki R.
AU - Sasaki, Iwao
AU - Kimura, Wataru
AU - Takano, Koji
AU - Obara, Takao
AU - Ishibashi, Miyuki
AU - Nakao, Kazuwa
AU - Doi, Ryuichiro
AU - Shimatsu, Akira
AU - Nishida, Toshirou
AU - Komoto, Izumi
AU - Hirata, Yukio
AU - Imamura, Masayuki
AU - Kawabe, Ken
AU - Nakamura, Kazuhiko
PY - 2007/6
Y1 - 2007/6
N2 - Background: We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004. Methods: Data on 1541 patients, 514 pancreatic endocrine tumors (PETs) and 1027 gastrointestinal carcinoids (GICs), were collected and analyzed. Results: Nonfunctioning tumors (NF-PET) constituted 47.7% of PETs. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETs was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively. Conclusions: The incidence of NETsin Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy.
AB - Background: We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004. Methods: Data on 1541 patients, 514 pancreatic endocrine tumors (PETs) and 1027 gastrointestinal carcinoids (GICs), were collected and analyzed. Results: Nonfunctioning tumors (NF-PET) constituted 47.7% of PETs. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETs was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively. Conclusions: The incidence of NETsin Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy.
KW - Endocrine pancreatic tumor
KW - Gastrointestinal carcinoid
KW - Nationwide survey
KW - Neuroendocrine tumor
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U2 - 10.1007/s00535-007-2056-6
DO - 10.1007/s00535-007-2056-6
M3 - Article
C2 - 17671766
AN - SCOPUS:34447343588
SN - 0944-1174
VL - 42
SP - 497
EP - 500
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
IS - 6
ER -