Quantification of red blood cell deformation at high-hematocrit blood flow in microvessels

Davod Alizadehrad, Yohsuke Imai, Keita Nakaaki, Takuji Ishikawa, Takami Yamaguchi

研究成果: Article査読

33 被引用数 (Scopus)


The deformation of red blood cells in microvessels was investigated numerically for various vessel diameters, hematocrits, and shear rates. We simulated blood flow in circular channels with diameters ranging from 9 to 50μm, hematocrits from 20% to 45%, and shear rates from 20 to 150s-1 using a particle-based model with parallel computing. The apparent viscosity predicted by the simulation was in good agreement with previous experimental results. We quantified the deformation of red blood cells as a function of radial position. The numerical results demonstrated that because of the shape transition in response to local shear stress and the wall effect, the radial variation of red blood cell deformation in relatively large microvessels could be classified into three different regions: near-center, middle, and near-wall regions. Effects of the local shear stress and wall varied with vessel diameter, hematocrit, and shear rate.

ジャーナルJournal of Biomechanics
出版ステータスPublished - 2012 10月 11

ASJC Scopus subject areas

  • 生物理学
  • 整形外科およびスポーツ医学
  • 生体医工学
  • リハビリテーション


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