@article{84ef490f2c19484a9c29d9fc41325fb6,
title = "Rhodium-Catalyzed Synthesis of Unsymmetric Di(heteroaryl)ureas Involving an Equilibrium Shift",
abstract = "Unsymmetric di(heteroaryl)ureas such as HetAr1-NHCONH-HetAr2 are efficiently synthesized from two symmetric ureas, HetAr1-NHCONH-HetAr1 and HetAr2-NHCONH-HetAr2, by rhodium-catalyzed exchange reactions. The equilibrium in some of the reactions can be shifted to the formation of unsymmetric ureas by the aggregation of the dimers formed by inter- and intramolecular hydrogen bonding.",
author = "Mieko Arisawa and Taro Mizuno and Kanako Nozawa-Kumada and Kaori Itto-Nakama and Miyu Furuta and Saori Tanii",
note = "Funding Information: The authors thank Dr. Eunsang Kwon (Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University) for his assistance in X-ray crystallographic analysis. This research was supported by the Japan Agency for Medical Research and Development (AMED), the Platform Project for Supporting Drug Discovery and Life Science Research (Grant JP19am0101100), the Tohoku University Center for Gender Equality Promotion (TUMUG), and the Morinomiyako Project for Empowering Women in Research. M.A. thanks the JST FOREST Program (Grant JPMJFR205X), the Yamada Science Foundation, the Kobayashi Foundation, and the Nagase Science and Technology Foundation. Publisher Copyright: {\textcopyright} 2021 American Chemical Society",
year = "2021",
month = dec,
day = "17",
doi = "10.1021/acs.orglett.1c03485",
language = "English",
volume = "23",
pages = "9382--9386",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "24",
}