Role of histone methylation and demethylation in adipogenesis and obesity

Masashi Okamura, Takeshi Inagaki, Toshiya Tanaka, Juro Sakai

研究成果: Review article査読

84 被引用数 (Scopus)

抄録

Adipocyte differentiation is a complex developmental process that involves the coordinated interplay of numerous transcription factors. PPARγ has emerged as a master regulator of adipogenesis and recent global target gene analysis demonstrated that PPARγ targets many genes encoding chromatin modification enzymes as well as genes of lipid metabolism and storage. Among such modification enzymes are histone lysine methyltransferases, which play important roles in transcriptional regulation. Histone methyltransferases are involved in PPARγ gene expression and subsequent adipogenesis. In addition, recent studies revealed that demethylation of histone H3 at lys9 is associated with resistance to obesity. We here review the role of histone methylation and demethylation in adipogenesis, metabolism and obesity.

本文言語English
ページ(範囲)24-32
ページ数9
ジャーナルOrganogenesis
6
1
DOI
出版ステータスPublished - 2010

ASJC Scopus subject areas

  • 生体医工学
  • 胎生学
  • 発生生物学
  • 移植

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