Safety and durability of the biodegradable felt in aortic surgery: A propensity score-matched study

Katsuhiro Hosoyama, Shunsuke Kawamoto, Koyu Watanabe, Yumi Sugawara, Yasuhiko Tabata, Masaya Yamamoto, Konosuke Sasaki, Koichi Tabayashi, Yoshikatsu Saiki

研究成果: Article査読

3 被引用数 (Scopus)


OBJECTIVES: Suture line disruption is a serious complication after aortic surgery. We previously reported in a canine model that basic fibroblast growth factor-incorporated biodegradable polyglycolic acid (PGA) felt prevented tissue derangement at the anastomotic site. This study sought to evaluate the safety and durability of this biodegradable felt. METHODS: Between January 2007 and December 2011, 67 patients who consented to undergo aortic surgery with the basic fibroblast growth factor-incorporated PGA felt were enrolled (Group P). As a control, we retrospectively reviewed the charts of 129 patients who underwent aortic surgery using a polytetrafluoroethylene felt during the same registration period (Group N). On the basis of 18 preoperative covariates, 60 well-matched patient pairs were identified using propensity matching, and their clinical indices were compared. RESULTS: Among the matched pairs, in-hospital mortality and postoperative complication rates did not statistically differ between the groups. During a median follow-up of 4.8 years, the rate of anastomotic aneurysm was 1.7% (1 patient) in both groups. The rates of overall survival and freedom from aortic events did not differ between the groups. In total, 65 anastomoses in Group P and 54 anastomoses in Group N were monitored via computed tomography, and the diameters of the juxta-anastomotic sites in Group N were more likely to be increased than those in Group P (dilatation ratio [(post-discharge diameter - predischarge diameter)/predischarge diameter×100 (%)]: 4.3% ± 0.6% vs 2.5% ± 0.5%, P = 0.01). CONCLUSIONS: The basic fibroblast growth factor-incorporated PGA felt was as safe and durable as conventional felt for reinforcement in aortic surgery. The attenuation of juxta-anastomotic aortic dilatation by PGA felt reinforcement may provide more beneficial effects on long-term outcomes.

ジャーナルEuropean Journal of Cardio-thoracic Surgery
出版ステータスPublished - 2018 8月 1

ASJC Scopus subject areas

  • 外科
  • 呼吸器内科
  • 循環器および心血管医学


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