Serotype Identification of Human Adenoviruses Associated with Influenza-Like Illnesses in the Philippines from 2006–2012 by Microneutralization and Molecular Techniques

Catherine Calzado-Dacasin, Janiza Lianne Foronda, Vina Lea Arguelles, Chona Mae Daga, Marie Therese Quimpo, Socorro Lupisan, Clyde Dapat, Mariko Saito, Michiko Okamoto, Pia Marie Albano, Hitoshi Oshitani

研究成果: Article査読

抄録

Objectives: Human adenoviruses (HAdV) are known to cause a wide range of diseases including acute respiratory infections, conjunctivitis, and acute gastroenteritis. In this study, we aimed to determine the serotypes of HAdV in patients with influenza-like illness (ILI) in the Philippines from 2006-2012 and to describe the demographic and epidemiological characteristics of patients who tested positive for HAdV. Methods: Between 2006 and 2012, the Philippine National Influenza Centre detected HAdV in 1294 samples of patients with ILI. Serotype determination was done in select samples using microneutralization, polymerase chain reaction (PCR), and sequencing methods. Results: A total of 8 serotypes were identified (HAdV 1–7 and 11), with HAdV-2 (27.8%), and HAdV-3 (27.8%) being the most prevalent. The majority of HAdV infections were found in children below 5 years of age (79.9%). Conclusions: The identification of HAdV circulating serotypes may serve as guide for designing disease intervention and control strategies and will provide important information regarding the contribution of this virus to respiratory infections, particularly in children, which remain a public health burden in the Philippines.

本文言語English
ページ(範囲)326-333
ページ数8
ジャーナルInternational Journal of Infectious Diseases
117
DOI
出版ステータスPublished - 2022 4月

ASJC Scopus subject areas

  • 微生物学(医療)
  • 感染症

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