TY - JOUR

T1 - Shear-induced diffusion of red blood cells in a semi-dilute suspension

AU - Omori, T.

AU - Ishikawa, T.

AU - Imai, Y.

AU - Yamaguchi, T.

PY - 2013/6/10

Y1 - 2013/6/10

N2 - The diffusion of red blood cells (RBCs) in blood is important to the physiology and pathology of the cardiovascular system. In this study, we investigate flow-induced diffusion of RBCs in a semi-dilute system by calculating the pairwise interactions between RBCs in simple shear flow. A capsule with a hyperelastic membrane was used to model an RBC. Its deformation was resolved using the finite element method, whereas fluid motion inside and outside the RBC was solved using the boundary element method. The results show that shear-induced RBC diffusion is significantly anisotropic, i.e. the velocity gradient direction component is larger than the vorticity direction. We also found that the motion of RBCs during the interaction is strongly dependent on the viscosity ratio of the internal to external fluid, and the diffusivity decreases monotonically as the viscosity ratio increases. The scaling argument also suggests that the diffusivity is proportional to the shear rate and haematocrit, if the suspension is in a semi-dilute environment and the capillary number is invariant. These fundamental findings are useful to understand transport phenomena in blood flow.

AB - The diffusion of red blood cells (RBCs) in blood is important to the physiology and pathology of the cardiovascular system. In this study, we investigate flow-induced diffusion of RBCs in a semi-dilute system by calculating the pairwise interactions between RBCs in simple shear flow. A capsule with a hyperelastic membrane was used to model an RBC. Its deformation was resolved using the finite element method, whereas fluid motion inside and outside the RBC was solved using the boundary element method. The results show that shear-induced RBC diffusion is significantly anisotropic, i.e. the velocity gradient direction component is larger than the vorticity direction. We also found that the motion of RBCs during the interaction is strongly dependent on the viscosity ratio of the internal to external fluid, and the diffusivity decreases monotonically as the viscosity ratio increases. The scaling argument also suggests that the diffusivity is proportional to the shear rate and haematocrit, if the suspension is in a semi-dilute environment and the capillary number is invariant. These fundamental findings are useful to understand transport phenomena in blood flow.

KW - biological fluid dynamics

KW - boundary integral methods

KW - capsule/cell dynamics

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U2 - 10.1017/jfm.2013.159

DO - 10.1017/jfm.2013.159

M3 - Article

AN - SCOPUS:84878324753

SN - 0022-1120

VL - 724

SP - 154

EP - 174

JO - Journal of Fluid Mechanics

JF - Journal of Fluid Mechanics

ER -