A 24-member combinatorial library based on the structure of aeruginosin 298-A (1a) was synthesized utilizing solid-phase, and their inhibitory activity against trypsin was evaluated. Among the library, we found that D-Hpla-D-Leu-L-Choi-Agma (1h) is 300 times more potent than the parent natural product 1a.
|ジャーナル||Journal of Combinatorial Chemistry|
|出版ステータス||Published - 2006 7月|
ASJC Scopus subject areas
- 化学 (全般)