Solid-phase combinatorial synthesis of aeruginosin derivatives and their biological evaluation

Takayuki Doi; Yoichiro Hoshina; Hiroyuki Mogi; Yoshifumi Yamada; Takashi Takahashi

doi:10.1021/cc0600270

Solid-phase combinatorial synthesis of aeruginosin derivatives and their biological evaluation

Takayuki Doi, Yoichiro Hoshina, Hiroyuki Mogi, Yoshifumi Yamada, Takashi Takahashi

研究成果: Article › 査読

31 被引用数 (Scopus)

抄録

A 24-member combinatorial library based on the structure of aeruginosin 298-A (1a) was synthesized utilizing solid-phase, and their inhibitory activity against trypsin was evaluated. Among the library, we found that D-Hpla-D-Leu-L-Choi-Agma (1h) is 300 times more potent than the parent natural product 1a.

本文言語	English
ページ（範囲）	571-582
ページ数	12
ジャーナル	Journal of Combinatorial Chemistry
巻	8
号	4
DOI	https://doi.org/10.1021/cc0600270
出版ステータス	Published - 2006 7月
外部発表	はい

ASJC Scopus subject areas

化学 (全般)

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10.1021/cc0600270

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引用スタイル

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abstract = "A 24-member combinatorial library based on the structure of aeruginosin 298-A (1a) was synthesized utilizing solid-phase, and their inhibitory activity against trypsin was evaluated. Among the library, we found that D-Hpla-D-Leu-L-Choi-Agma (1h) is 300 times more potent than the parent natural product 1a.",

author = "Takayuki Doi and Yoichiro Hoshina and Hiroyuki Mogi and Yoshifumi Yamada and Takashi Takahashi",

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Solid-phase combinatorial synthesis of aeruginosin derivatives and their biological evaluation

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