TY - JOUR
T1 - Sonodynamic therapy with anticancer micelles and high-intensity focused ultrasound in treatment of canine cancer
AU - Horise, Yuki
AU - Maeda, Masanori
AU - Konishi, Yoshiyuki
AU - Okamoto, Jun
AU - Ikuta, Soko
AU - Okamoto, Yoshiharu
AU - Ishii, Hiroshi
AU - Yoshizawa, Shin
AU - Umemura, Shinichiro
AU - Ueyama, Tsuyoshi
AU - Tamano, Satoshi
AU - Sofuni, Atsushi
AU - Takemae, Kazuhisa
AU - Masamune, Ken
AU - Iseki, Hiroshi
AU - Nishiyama, Nobuhiro
AU - Kataoka, Kazunori
AU - Muragaki, Yoshihiro
N1 - Funding Information:
This study was supported by the funding programs of the Center of Innovation (COI), the Japan Science and Technology Agency (JST, JPMJCE1305), and the Japan Agency for Medical Research and Development (AMED, JP17hk0102028).
Publisher Copyright:
Copyright © 2019 Horise, Maeda, Konishi, Okamoto, Ikuta, Okamoto, Ishii, Yoshizawa, Umemura, Ueyama, Tamano, Sofuni, Takemae, Masamune, Iseki, Nishiyama, Kataoka and Muragaki. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
PY - 2019
Y1 - 2019
N2 - Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocellular cancer, and prostate cancer. The fact that no adverse events were observed, suggests the usefulness of SDT.
AB - Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocellular cancer, and prostate cancer. The fact that no adverse events were observed, suggests the usefulness of SDT.
KW - Anticancer micelles
KW - Drug delivery system
KW - High-intensity focused ultrasound
KW - Minimally invasive
KW - Sonodynamic therapy
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U2 - 10.3389/fphar.2019.00545
DO - 10.3389/fphar.2019.00545
M3 - Article
AN - SCOPUS:85068829543
SN - 1663-9812
VL - 10
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
IS - MAY
M1 - 545
ER -
