Strigolactone perception and deactivation by a hydrolase receptor DWARF14

Yoshiya Seto, Rei Yasui, Hiromu Kameoka, Muluneh Tamiru, Mengmeng Cao, Ryohei Terauchi, Akane Sakurada, Rena Hirano, Takaya Kisugi, Atsushi Hanada, Mikihisa Umehara, Eunjoo Seo, Kohki Akiyama, Jason Burke, Noriko Takeda-Kamiya, Weiqiang Li, Yoshinori Hirano, Toshio Hakoshima, Kiyoshi Mashiguchi, Joseph P. NoelJunko Kyozuka, Shinjiro Yamaguchi

研究成果: Article査読

124 被引用数 (Scopus)


The perception mechanism for the strigolactone (SL) class of plant hormones has been a subject of debate because their receptor, DWARF14 (D14), is an α/β-hydrolase that can cleave SLs. Here we show via time-course analyses of SL binding and hydrolysis by Arabidopsis thaliana D14, that the level of uncleaved SL strongly correlates with the induction of the active signaling state. In addition, we show that an AtD14 D218A catalytic mutant that lacks enzymatic activity is still able to complement the atd14 mutant phenotype in an SL-dependent manner. We conclude that the intact SL molecules trigger the D14 active signaling state, and we also describe that D14 deactivates bioactive SLs by the hydrolytic degradation after signal transmission. Together, these results reveal that D14 is a dual-functional receptor, responsible for both the perception and deactivation of bioactive SLs.

ジャーナルNature communications
出版ステータスPublished - 2019 12月 1

ASJC Scopus subject areas

  • 化学 (全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 一般
  • 物理学および天文学(全般)


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