@article{777e9f257b734b9d96264dcbcc2b42cb,
title = "Studies toward the Total Synthesis of Caribbean Ciguatoxin C-CTX-1: Synthesis of the LMN-Ring Fragment through Reductive Olefin Cross-Coupling",
abstract = "Synthesis of the LMN-ring fragment of Caribbean ciguatoxin C-CTX-1, the principal causative toxin for ciguatera fish poisoning around the Caribbean Sea areas, is described. The key feature of the synthesis is the stereoselective introduction of an angular methyl group on the sterically encumbered seven-membered M-ring by the application of a hydrogen atom transfer-based reductive olefin coupling.",
author = "Makoto Sasaki and Kotaro Iwasaki and Keisuke Arai",
note = "Funding Information: This work was financially supported by JSPS KAKENHI Grant JP16H03278. We are grateful to Emeritus Professor Masahiro Hirama of Tohoku University for his encouragement. We also thank Ms. Yuka Taguchi (Tohoku University) for FAB mass measurements. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = nov,
day = "16",
doi = "10.1021/acs.orglett.8b03102",
language = "English",
volume = "20",
pages = "7163--7166",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "22",
}