TY - JOUR
T1 - Successful liver transplantation from agonal non-heart-beating donors in pigs
AU - Sato, Masahide
AU - Ohkohchi, Nobuhiro
AU - Tsukamoto, Shigeki
AU - Koyamada, Nozomi
AU - Asakura, Takeshi
AU - Enomoto, Yoshitaka
AU - Usuda, Masahiro
AU - Miyagi, Shigehito
AU - Okada, Akiho
AU - Satomi, Susumu
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - An effective way to overcome shortage of donors in liver transplantation (LTx) is to consider such from non-heart-beating donors (NHBDs). We investigated how a liver graft should be treated before and/or after procurement for successful LTx from an NHBD. Porcine LTx was performed with FR167653 (FR), a dual inhibitor of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and/or prostaglandin E1 (PG). Animals were allocated to an FR group (n = 4, donors and recipients were treated with FR), a PG group (n = 4, donors and recipients were treated with PG), or an FRPG group (n = 4, donors and recipients were treated with both FR and PG). No recipients in the FR group and only two of four recipients in the PG group survived, whereas all recipients in the FRPG group survived. Suppression of TNF-α and IL-1β and maintenance of microcirculation are the key to successful transplantation from NHBDs.
AB - An effective way to overcome shortage of donors in liver transplantation (LTx) is to consider such from non-heart-beating donors (NHBDs). We investigated how a liver graft should be treated before and/or after procurement for successful LTx from an NHBD. Porcine LTx was performed with FR167653 (FR), a dual inhibitor of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and/or prostaglandin E1 (PG). Animals were allocated to an FR group (n = 4, donors and recipients were treated with FR), a PG group (n = 4, donors and recipients were treated with PG), or an FRPG group (n = 4, donors and recipients were treated with both FR and PG). No recipients in the FR group and only two of four recipients in the PG group survived, whereas all recipients in the FRPG group survived. Suppression of TNF-α and IL-1β and maintenance of microcirculation are the key to successful transplantation from NHBDs.
KW - Liver transplantation Non-heart-beating donor
KW - Reperfusion injury
KW - Warm ischemic injury
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U2 - 10.1111/j.1432-2277.2003.tb00270.x
DO - 10.1111/j.1432-2277.2003.tb00270.x
M3 - Article
C2 - 12595971
AN - SCOPUS:0038655439
SN - 0934-0874
VL - 16
SP - 100
EP - 107
JO - Transplant International
JF - Transplant International
IS - 2
ER -