TY - JOUR
T1 - Suppression of bradykinin-induced renin release by indomethacin in anesthetized rats
AU - Suzuki, Mizue
AU - Satoh, Susumu
N1 - Funding Information:
ACKNOWLEDGMENT This work was partially supported by a Grant-in-Aid for Scientific Research (Japan).
PY - 1984
Y1 - 1984
N2 - The present study was designed to investigate the effect of bradykinin on renin release in relation to prostaglandins by use of indomethacin, a cyclooxygenase inhibitor, in pentobarbital-anesthetized rats. A nonhypotensive dose of bradykinin (1 μg/kg. min), which was infused intrarenally, significantly increased plasma renin activity approximately 1.8-fold as compared to the control period. In indomethacin (5 mg/kg, i.v.)-pretreated rats, bradykinin did not significantly increase plasma renin activity. These results suggest that bradykinin does not directly increase plasma renin activity and that prostaglandins may participate in the bradykinin-induced renin release under these experimental conditions
AB - The present study was designed to investigate the effect of bradykinin on renin release in relation to prostaglandins by use of indomethacin, a cyclooxygenase inhibitor, in pentobarbital-anesthetized rats. A nonhypotensive dose of bradykinin (1 μg/kg. min), which was infused intrarenally, significantly increased plasma renin activity approximately 1.8-fold as compared to the control period. In indomethacin (5 mg/kg, i.v.)-pretreated rats, bradykinin did not significantly increase plasma renin activity. These results suggest that bradykinin does not directly increase plasma renin activity and that prostaglandins may participate in the bradykinin-induced renin release under these experimental conditions
KW - Bradykinin
KW - Indomethacin
KW - Plasma renin activity
KW - Prostaglandins
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U2 - 10.3109/10641968409039593
DO - 10.3109/10641968409039593
M3 - Article
C2 - 6430607
AN - SCOPUS:0021270654
SN - 1064-1963
VL - A6
SP - 1227
EP - 1235
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
IS - 6
ER -