@article{35a6b966dd6f4c6eba91de725cc01b87,
title = "Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer",
abstract = "We have developed a practical synthetic route to construct C-aromatic taxane derivatives as three-dimension templates by way of intramolecular alkylation. The usefulness of synthesized compounds as the core template was evaluated by using a newly developed screening system for P-glycoprotein.",
keywords = "Multidrug resistance reversal agents",
author = "Takashi Takahashi and Kazuoki Nakai and Takayuki Doi and Masa Yasunaga and Hiroshi Nakagawa and Toshihisa Ishikawa",
note = "Funding Information: The authors cordially thank Prof. Kazumitsu Ueda (Kyoto Univ.) for generously providing us with MDR KB-G2 and parental KB-3-1 cells. This work was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology, Japan (No. 14103013 to T.T.) as well as a research grant (No. 13NP0401 to T.I.) for Creative Scientific Research from the Japan Society for the Promotion of Science.",
year = "2005",
month = may,
day = "16",
doi = "10.1016/j.bmcl.2005.03.038",
language = "English",
volume = "15",
pages = "2601--2605",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "10",
}
