@article{df3cbb9327b54caabd08c471f843d3c7,
title = "Targeting selective autophagy by AUTAC degraders",
abstract = "Targeted degradation is a promising new modality in drug discovery that makes it possible to reduce intracellular protein levels with small molecules. It is a complementary approach to the conventional protein knockdown typically used in laboratories and may offer a way to approach the currently undruggable human proteome. Recently, the first autophagy-mediated degraders, called AUTACs, were developed based on observations in a xenophagy study.",
keywords = "AUTAC, drug discovery, guanylation, mitophagy, PROTAC, targeted degradation",
author = "Daiki Takahashi and Hirokazu Arimoto",
note = "Funding Information: This work is supported by supported by the Ministry of Education, Culture, Sports, Science, and Technology, Japan Society for the Promotion of Science (MEXT, JSPS), KAKENHI (grant numbers JP17K19190, JP18H04604, JP18H04377, JP19H02844). Publisher Copyright: {\textcopyright} 2020, {\textcopyright} 2020 Informa UK Limited, trading as Taylor & Francis Group.",
year = "2020",
month = apr,
day = "2",
doi = "10.1080/15548627.2020.1718362",
language = "English",
volume = "16",
pages = "765--766",
journal = "Autophagy",
issn = "1554-8627",
publisher = "Landes Bioscience",
number = "4",
}