Temporo-parietal theta activity correlates with misery perfusion in arterial occlusive disease

Satoru Ohtomo, Nobukazu Nakasato, Hiroaki Shimizu, Shintarou Seki, Akitake Kanno, Toshihiro Kumabe, Teiji Tominaga

研究成果: ジャーナルへの寄稿学術論文査読

6 被引用数 (Scopus)

抄録

Objective: Temporo-parietal theta activity (TPTA), often detected in hemispheres with internal carotid (ICA) or middle cerebral artery (MCA) occlusive lesions, is more clearly separated from occipital alpha activity by magnetoencephalography (MEG) than electroencephalography. The present study investigated whether TPTA is correlated with misery perfusion, a surgically correctable type of hemodynamic impairment. Methods: Awake MEG was measured in 56 patients with ICA or MCA occlusive lesions. Regional cerebral blood flow (rCBF) and regional cerebrovascular reactivity (rCVR) to acetazolamide were measured in the MCA territory by xenon-133 single-photon emission computed tomography. MEG was repeated in 10 patients after vascular reconstruction surgery. Results: Fourteen patients showed TPTA in the lesion hemisphere (n = 13) or bilaterally (n = 1). The presence of TPTA was significantly correlated with both reduced rCBF and reduced rCVR (P = 0.0009). After surgery, TPTA disappeared in 7 of the 10 studied patients. Conclusions: The presence of TPTA suggests misery perfusion, which is characterized by reduced rCBF and reduced rCVR. Significance: MEG can detect the presence of reversible and surgically remediable cerebral ischemia before the development of complete infarction.

本文言語英語
ページ(範囲)1227-1234
ページ数8
ジャーナルClinical Neurophysiology
120
7
DOI
出版ステータス出版済み - 2009 7月

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