@article{b0fbf563c59b465ebf41a5550854fef8,
title = "The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons",
abstract = "TDP-43 and FUS are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), and loss of function of either protein contributes to these neurodegenerative conditions. To elucidate the TDP-43- and FUS-regulated pathophysiological RNA metabolism cascades, we assessed the differential gene expression and alternative splicing profiles related to regulation by either TDP-43 or FUS in primary cortical neurons. These profiles overlapped by >25% with respect to gene expression and >9% with respect to alternative splicing. The shared downstream RNA targets of TDP-43 and FUS may form a common pathway in the neurodegenerative processes of ALS/FTLD.",
keywords = "ALS, FTLD, FUS, TDP-43, Transcriptome",
author = "Daiyu Honda and Shinsuke Ishigaki and Yohei Iguchi and Yusuke Fujioka and Tsuyoshi Udagawa and Akio Masuda and Kinji Ohno and Masahisa Katsuno and Gen Sobue",
note = "Funding Information: Part of this study represents the results of the “Integrated Research on Neuropsychiatric Disorders” project, which has been conducted under the Strategic Research Program for Brain Sciences of the Ministry of Education, Culture, Sports, Science and Technology of Japan. This work was also supported by grants-in-aid from the CREST/JST , MEXT , and MHLW of Japan . ",
year = "2014",
doi = "10.1016/j.fob.2013.11.001",
language = "English",
volume = "4",
pages = "1--10",
journal = "FEBS Open Bio",
issn = "2211-5463",
publisher = "Elsevier BV",
}