The bacterial flagellar cap as the rotary promoter of flagellin self-assembly

K. Yonekura, S. Maki, D. G. Morgan, D. J. DeRosier, F. Vonderviszt, K. Imada, K. Namba

研究成果: ジャーナルへの寄稿学術論文査読

169 被引用数 (Scopus)

抄録

The growth of the bacterial flagellar filament occurs at its distal end by self-assembly of flagellin transported from the cytoplasm through the narrow central channel. The cap at the growing end is essential for its growth, remaining stably attached while permitting the flagellin insertion. In order to understand the assembly mechanism, we used electron microscopy to study the structures of the cap-filament complex and isolated cap dimer. Five leg-like anchor domains of the pentameric cap flexibly adjusted their conformations to keep just one flagellin binding site open, indicating a cap rotation mechanism to promote the flagellin self-assembly. This represents one of the most dynamic movements in protein structures.

本文言語英語
ページ(範囲)2148-2152
ページ数5
ジャーナルScience
290
5499
DOI
出版ステータス出版済み - 2000 12月 15

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