The design of molecular sensing interfaces with lipid-bilayer assemblies

Ayumi Hirano-Iwata, Michio Niwano, Masao Sugawara

研究成果: ジャーナルへの寄稿学術論文査読

65 被引用数 (Scopus)

抄録

We describe the current status of techniques for preparing planar lipid bilayers, the fusion of sensory elements and the design of bilayer interfaces for analytical applications. Advances in bilayer fabrication have allowed preparation of lipid bilayers with membrane resistance of >1 GΩ ("gigaseal") in flow, microfluidic and array formats, which have enabled single-channel and multi-channel recording. Not only biological but also engineered channels have been adopted as sensory elements for lipid-bilayer-based biosensors. Synthetic and inorganic channels are also emerging for designing membranes for lipid-bilayer sensors. We discuss the potential of lipid bilayers containing biological, engineered or synthetic channels for the design of biosensors, including drug-screening biosensors.

本文言語英語
ページ(範囲)512-520
ページ数9
ジャーナルTrAC - Trends in Analytical Chemistry
27
6
DOI
出版ステータス出版済み - 2008 6月

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