Three cases of kindred with familial breast cancer in which carrier detection by BRCA gene testing was performed on family members

Tadashi Nomizu, Takeshi Sakuma, Mutsuo Yamada, Masami Matsuzaki, Naoto Katagata, Fumiaki Watanabe, Mitsuhiro Nihei, Chikashi Ishioka, Seiichi Takenoshita, Rikiya Abe

研究成果: ジャーナルへの寄稿学術論文査読

1 被引用数 (Scopus)

抄録

We performed presymptomatic carrier detection by BRCA gene testing of the family members of three familial breast cancer kindred diagnosed with pathogenetic mutation in BRCA genes. All members were over 20 years of age. We explained familial breast cancer and BRCA gene testing, and obtained autonomic consent before gene testing. Genetic testing revealed twins in a family were dizygotic. In another family bilateral breast cancer occurred in a carrier after five years of genetic testing. Carriers are at high risk of breast cancer and have to receive breast cancer screening and familial tumor counseling. Non-carriers are at the same risk of breast cancer as the general population.

本文言語英語
ページ(範囲)270-274
ページ数5
ジャーナルBreast Cancer
19
3
DOI
出版ステータス出版済み - 2012 7月

フィンガープリント

「Three cases of kindred with familial breast cancer in which carrier detection by BRCA gene testing was performed on family members」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル