Three-dimensional solution structure of EM703 with potent promoting activity of monocyte-to-macrophage differentiation

Hiroaki Gouda, Toshiaki Sunazuka, Kiminari Yoshida, Akihiro Sugawara, Yusuke Sakoh, Satoshi Omura, Shuichi Hirono

研究成果: ジャーナルへの寄稿学術論文査読

8 被引用数 (Scopus)

抄録

EM703, which is an erythromycin derivative synthesized by our group, has a potent promoting activity of monocyte-to-macrophage differentiation in vitro. Its activity is approximately 300 times higher than that of erythromycin A (EM-A). In this study, we determined three-dimensional (3D) solution structures of EM703 and EM-A, and compared them using a superposition method, in order to investigate the 3D structure-activity relationship. We found a distinct difference between the 3D structures of these molecules, which might be an important factor in their divergent activities.

本文言語英語
ページ(範囲)2496-2499
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
16
9
DOI
出版ステータス出版済み - 2006 5月 1

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