抄録
The first total synthesis of chiriquitoxin, the most structurally complex analogue of tetrodotoxin isolated from a Costa Rican dart frog, has been accomplished from a newly designed intermediate for a variety of tetrodotoxin derivatives. The synthesis includes the third total synthesis of tetrodotoxin in this laboratory, and its intermediate was transformed into chiriquitoxin by a stereocontrolled aldol reaction with a d-camphor-derived lactone for installation of the unique side chain, and a new deprotection of methylthiomethyl (MTM) ether by using a Pummerer rearrangement.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 1247-1251 |
| ページ数 | 5 |
| ジャーナル | Chemistry - A European Journal |
| 巻 | 20 |
| 号 | 5 |
| DOI | |
| 出版ステータス | Published - 2014 1月 27 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 触媒
- 有機化学