Tumor Microenvironment in Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: Interaction between Tumors and Immune Cells, and Potential Effects of Neuroendocrine Differentiation on the Tumor Microenvironment

Junichi Tsunokake; Fumiyoshi Fujishima; Hirofumi Watanabe; Ikuro Sato; Koh Miura; Kazuhiro Sakamoto; Hiroyoshi Suzuki; Takashi Sawai; Yuko Itakura; Tatsuya Hoshi; Atsushi Kunimitsu; Takuro Yamauchi; Ryujiro Akaishi; Yohei Ozawa; Toshiaki Fukutomi; Hiroshi Okamoto; Chiaki Sato; Yusuke Taniyama; Takashi Kamei; Hironobu Sasano

doi:10.3390/cancers14092152

Tumor Microenvironment in Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: Interaction between Tumors and Immune Cells, and Potential Effects of Neuroendocrine Differentiation on the Tumor Microenvironment

Junichi Tsunokake, Fumiyoshi Fujishima, Hirofumi Watanabe, Ikuro Sato, Koh Miura, Kazuhiro Sakamoto, Hiroyoshi Suzuki, Takashi Sawai, Yuko Itakura, Tatsuya Hoshi, Atsushi Kunimitsu, Takuro Yamauchi, Ryujiro Akaishi, Yohei Ozawa, Toshiaki Fukutomi, Hiroshi Okamoto, Chiaki Sato, Yusuke Taniyama, Takashi Kamei, Hironobu Sasano

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

抄録

The tumor microenvironment is considered to play a pivotal role in various human malignancies. Neuroendocrine and non-neuroendocrine neoplasms are considered to have different tumor microenvironments. However, owing to differences in the systemic and/or local immune statuses, tumor microenvironments in different patients may be difficult to compare. Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs), although rare, could be useful for exploring the effects of neuroendocrine differentiation on the tumor microenvironment, because both neuroendocrine and non-neuroendocrine components are present in the same tumor. Here, we examined 33 cases.

本文言語	英語
論文番号	2152
ジャーナル	Cancers
巻	14
号	9
DOI	https://doi.org/10.3390/cancers14092152
出版ステータス	出版済み - 2022 5月 1

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.3390/cancers14092152

他のファイルとリンク

フィンガープリント

「Tumor Microenvironment in Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: Interaction between Tumors and Immune Cells, and Potential Effects of Neuroendocrine Differentiation on the Tumor Microenvironment」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Tsunokake, J., Fujishima, F., Watanabe, H., Sato, I., Miura, K., Sakamoto, K., Suzuki, H., Sawai, T., Itakura, Y., Hoshi, T., Kunimitsu, A., Yamauchi, T., Akaishi, R., Ozawa, Y., Fukutomi, T., Okamoto, H., Sato, C., Taniyama, Y., Kamei, T., & Sasano, H. (2022). Tumor Microenvironment in Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: Interaction between Tumors and Immune Cells, and Potential Effects of Neuroendocrine Differentiation on the Tumor Microenvironment. Cancers, 14(9), Article 2152. https://doi.org/10.3390/cancers14092152

@article{d6848bd6dc784c119244f53975615e0a,

title = "Tumor Microenvironment in Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: Interaction between Tumors and Immune Cells, and Potential Effects of Neuroendocrine Differentiation on the Tumor Microenvironment",

abstract = "The tumor microenvironment is considered to play a pivotal role in various human malignancies. Neuroendocrine and non-neuroendocrine neoplasms are considered to have different tumor microenvironments. However, owing to differences in the systemic and/or local immune statuses, tumor microenvironments in different patients may be difficult to compare. Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs), although rare, could be useful for exploring the effects of neuroendocrine differentiation on the tumor microenvironment, because both neuroendocrine and non-neuroendocrine components are present in the same tumor. Here, we examined 33 cases.",

keywords = "angiogenesis, immune suppression, mixed neuroendocrine non-neuroendocrine neoplasms, neuroendocrine differentiation, tumor infiltrating lymphocyte, tumor microenvironment",

author = "Junichi Tsunokake and Fumiyoshi Fujishima and Hirofumi Watanabe and Ikuro Sato and Koh Miura and Kazuhiro Sakamoto and Hiroyoshi Suzuki and Takashi Sawai and Yuko Itakura and Tatsuya Hoshi and Atsushi Kunimitsu and Takuro Yamauchi and Ryujiro Akaishi and Yohei Ozawa and Toshiaki Fukutomi and Hiroshi Okamoto and Chiaki Sato and Yusuke Taniyama and Takashi Kamei and Hironobu Sasano",

note = "Funding Information: Funding: Financial support for the present study was partly provided by Novartis Pharma K.K. (Tokyo, Japan). Novartis Pharma K.K. had no role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = may,

day = "1",

doi = "10.3390/cancers14092152",

language = "English",

volume = "14",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "9",

}

Tsunokake, J, Fujishima, F , Watanabe, H, Sato, I, Miura, K, Sakamoto, K, Suzuki, H, Sawai, T, Itakura, Y, Hoshi, T, Kunimitsu, A, Yamauchi, T, Akaishi, R, Ozawa, Y, Fukutomi, T, Okamoto, H , Sato, C , Taniyama, Y , Kamei, T & Sasano, H 2022, 'Tumor Microenvironment in Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: Interaction between Tumors and Immune Cells, and Potential Effects of Neuroendocrine Differentiation on the Tumor Microenvironment', Cancers, vol. 14, no. 9, 2152. https://doi.org/10.3390/cancers14092152

Tumor Microenvironment in Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: Interaction between Tumors and Immune Cells, and Potential Effects of Neuroendocrine Differentiation on the Tumor Microenvironment. / Tsunokake, Junichi; Fujishima, Fumiyoshi ; Watanabe, Hirofumi その他.
In: Cancers, Vol. 14, No. 9, 2152, 01.05.2022.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

TY - JOUR

T1 - Tumor Microenvironment in Mixed Neuroendocrine Non-Neuroendocrine Neoplasms

T2 - Interaction between Tumors and Immune Cells, and Potential Effects of Neuroendocrine Differentiation on the Tumor Microenvironment

AU - Tsunokake, Junichi

AU - Fujishima, Fumiyoshi

AU - Watanabe, Hirofumi

AU - Sato, Ikuro

AU - Miura, Koh

AU - Sakamoto, Kazuhiro

AU - Suzuki, Hiroyoshi

AU - Sawai, Takashi

AU - Itakura, Yuko

AU - Hoshi, Tatsuya

AU - Kunimitsu, Atsushi

AU - Yamauchi, Takuro

AU - Akaishi, Ryujiro

AU - Ozawa, Yohei

AU - Fukutomi, Toshiaki

AU - Okamoto, Hiroshi

AU - Sato, Chiaki

AU - Taniyama, Yusuke

AU - Kamei, Takashi

AU - Sasano, Hironobu

N1 - Funding Information: Funding: Financial support for the present study was partly provided by Novartis Pharma K.K. (Tokyo, Japan). Novartis Pharma K.K. had no role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/5/1

Y1 - 2022/5/1

N2 - The tumor microenvironment is considered to play a pivotal role in various human malignancies. Neuroendocrine and non-neuroendocrine neoplasms are considered to have different tumor microenvironments. However, owing to differences in the systemic and/or local immune statuses, tumor microenvironments in different patients may be difficult to compare. Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs), although rare, could be useful for exploring the effects of neuroendocrine differentiation on the tumor microenvironment, because both neuroendocrine and non-neuroendocrine components are present in the same tumor. Here, we examined 33 cases.

AB - The tumor microenvironment is considered to play a pivotal role in various human malignancies. Neuroendocrine and non-neuroendocrine neoplasms are considered to have different tumor microenvironments. However, owing to differences in the systemic and/or local immune statuses, tumor microenvironments in different patients may be difficult to compare. Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs), although rare, could be useful for exploring the effects of neuroendocrine differentiation on the tumor microenvironment, because both neuroendocrine and non-neuroendocrine components are present in the same tumor. Here, we examined 33 cases.

KW - angiogenesis

KW - immune suppression

KW - mixed neuroendocrine non-neuroendocrine neoplasms

KW - neuroendocrine differentiation

KW - tumor infiltrating lymphocyte

KW - tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=85128775606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85128775606&partnerID=8YFLogxK

U2 - 10.3390/cancers14092152

DO - 10.3390/cancers14092152

M3 - Article

AN - SCOPUS:85128775606

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 9

M1 - 2152

ER -