Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi

Ying Ye; Atsushi Minami; Yuya Igarashi; Miho Izumikawa; Myco Umemura; Nozomi Nagano; Masayuki Machida; Teppei Kawahara; Kazuo Shin-ya; Katsuya Gomi; Hideaki Oikawa

doi:10.1002/anie.201602611

Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi

Ying Ye, Atsushi Minami, Yuya Igarashi, Miho Izumikawa, Myco Umemura, Nozomi Nagano, Masayuki Machida, Teppei Kawahara, Kazuo Shin-ya, Katsuya Gomi, Hideaki Oikawa

研究成果: Article › 査読

57 被引用数 (Scopus)

抄録

The biosynthetic machinery of the first fungal ribosomally synthesized and post-translationally modified peptide (RiPP) ustiloxin B was elucidated through a series of gene inactivation and heterologous expression studies. The results confirmed an essential requirement for novel oxidases possessing the DUF3328 motif for macrocyclization, and highly unique side-chain modifications by three oxidases (UstCF1F2) and a pyridoxal 5′-phosphate (PLP)-dependent enzyme (UstD). These findings provide new insight into the expression of the RiPP gene clusters found in various fungi.

本文言語	English
ページ（範囲）	8072-8075
ページ数	4
ジャーナル	Angewandte Chemie - International Edition
巻	55
号	28
DOI	https://doi.org/10.1002/anie.201602611
出版ステータス	Published - 2016 7月 4

ASJC Scopus subject areas

触媒
化学 (全般)

文献へのアクセス

10.1002/anie.201602611

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「Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Ye, Y., Minami, A., Igarashi, Y., Izumikawa, M., Umemura, M., Nagano, N., Machida, M., Kawahara, T., Shin-ya, K., Gomi, K., & Oikawa, H. (2016). Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi. Angewandte Chemie - International Edition, 55(28), 8072-8075. https://doi.org/10.1002/anie.201602611

Ye, Y, Minami, A, Igarashi, Y, Izumikawa, M, Umemura, M, Nagano, N, Machida, M, Kawahara, T, Shin-ya, K, Gomi, K & Oikawa, H 2016, 'Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi', Angewandte Chemie - International Edition, vol. 55, no. 28, pp. 8072-8075. https://doi.org/10.1002/anie.201602611

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abstract = "The biosynthetic machinery of the first fungal ribosomally synthesized and post-translationally modified peptide (RiPP) ustiloxin B was elucidated through a series of gene inactivation and heterologous expression studies. The results confirmed an essential requirement for novel oxidases possessing the DUF3328 motif for macrocyclization, and highly unique side-chain modifications by three oxidases (UstCF1F2) and a pyridoxal 5′-phosphate (PLP)-dependent enzyme (UstD). These findings provide new insight into the expression of the RiPP gene clusters found in various fungi.",

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