Up-regulation of the claudin-6 gene in adipogenesis

Yeon Hee Hong; Daisuke Hishikawa; Hisae Miyahara; Yukihiko Nishimura; Hiroaki Tsuzuki; Chizu Gotoh; Tomoyo Iga; Yasuki Suzuki; Sang Houn Song; Ki Choon Choi; Hong Gu Lee; Shinichi Sasaki; Sang Gun Roh

doi:10.1271/bbb.69.2117

Up-regulation of the claudin-6 gene in adipogenesis

Yeon Hee Hong, Daisuke Hishikawa, Hisae Miyahara, Yukihiko Nishimura, Hiroaki Tsuzuki, Chizu Gotoh, Tomoyo Iga, Yasuki Suzuki, Sang Houn Song, Ki Choon Choi, Hong Gu Lee, Shinichi Sasaki, Sang Gun Roh

研究成果: Article › 査読

7 被引用数 (Scopus)

抄録

To investigate the role of claudin-6 in adipogenesis, claudin-6 mRNA was examined in adipose tissues and adipocyte differentiation. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet as compared to a normal-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 cells in vitro. Moreover, small interfering RNA (siRNA)-mediated reduction of claudin-6 mRNA inhibited differentiation of 3T3-L1 cells. These results suggest that claudin-6 is another important regulator in adipogenesis and fat deposition.

本文言語	English
ページ（範囲）	2117-2121
ページ数	5
ジャーナル	Bioscience, Biotechnology and Biochemistry
巻	69
号	11
DOI	https://doi.org/10.1271/bbb.69.2117
出版ステータス	Published - 2005
外部発表	はい

ASJC Scopus subject areas

バイオテクノロジー
分析化学
生化学
応用微生物学とバイオテクノロジー
分子生物学
有機化学

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10.1271/bbb.69.2117

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title = "Up-regulation of the claudin-6 gene in adipogenesis",

abstract = "To investigate the role of claudin-6 in adipogenesis, claudin-6 mRNA was examined in adipose tissues and adipocyte differentiation. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet as compared to a normal-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 cells in vitro. Moreover, small interfering RNA (siRNA)-mediated reduction of claudin-6 mRNA inhibited differentiation of 3T3-L1 cells. These results suggest that claudin-6 is another important regulator in adipogenesis and fat deposition.",

keywords = "Adipogenesis, Adipose tissue, Claudin-6, Fat depot, High-fat diet",

author = "Hong, {Yeon Hee} and Daisuke Hishikawa and Hisae Miyahara and Yukihiko Nishimura and Hiroaki Tsuzuki and Chizu Gotoh and Tomoyo Iga and Yasuki Suzuki and Song, {Sang Houn} and Choi, {Ki Choon} and Lee, {Hong Gu} and Shinichi Sasaki and Roh, {Sang Gun}",

note = "Funding Information: This work was supported in part by a Grant-in-Aid (no. 17380168 to S.-G. R.) for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.",

year = "2005",

doi = "10.1271/bbb.69.2117",

language = "English",

volume = "69",

pages = "2117--2121",

journal = "Bioscience, Biotechnology and Biochemistry",

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T1 - Up-regulation of the claudin-6 gene in adipogenesis

AU - Hong, Yeon Hee

AU - Hishikawa, Daisuke

AU - Miyahara, Hisae

AU - Nishimura, Yukihiko

AU - Tsuzuki, Hiroaki

AU - Gotoh, Chizu

AU - Iga, Tomoyo

AU - Suzuki, Yasuki

AU - Song, Sang Houn

AU - Choi, Ki Choon

AU - Lee, Hong Gu

AU - Sasaki, Shinichi

AU - Roh, Sang Gun

N1 - Funding Information: This work was supported in part by a Grant-in-Aid (no. 17380168 to S.-G. R.) for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2005

Y1 - 2005

N2 - To investigate the role of claudin-6 in adipogenesis, claudin-6 mRNA was examined in adipose tissues and adipocyte differentiation. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet as compared to a normal-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 cells in vitro. Moreover, small interfering RNA (siRNA)-mediated reduction of claudin-6 mRNA inhibited differentiation of 3T3-L1 cells. These results suggest that claudin-6 is another important regulator in adipogenesis and fat deposition.

AB - To investigate the role of claudin-6 in adipogenesis, claudin-6 mRNA was examined in adipose tissues and adipocyte differentiation. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet as compared to a normal-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 cells in vitro. Moreover, small interfering RNA (siRNA)-mediated reduction of claudin-6 mRNA inhibited differentiation of 3T3-L1 cells. These results suggest that claudin-6 is another important regulator in adipogenesis and fat deposition.

KW - Adipogenesis

KW - Adipose tissue

KW - Claudin-6

KW - Fat depot

KW - High-fat diet

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AN - SCOPUS:28244488177

SN - 0916-8451

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JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

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ER -

Up-regulation of the claudin-6 gene in adipogenesis

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