Visualization of murine lymph vessels using photoacoustic imaging with contrast agents

Ryo Nagaoka; Takuya Tabata; Shin Yoshizawa; Shin ichiro Umemura; Yoshifumi Saijo

doi:10.1016/j.pacs.2018.01.001

Visualization of murine lymph vessels using photoacoustic imaging with contrast agents

Ryo Nagaoka, Takuya Tabata, Shin Yoshizawa, Shin ichiro Umemura, Yoshifumi Saijo

研究成果: Article › 査読

17 被引用数 (Scopus)

抄録

Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of scattered light was evaluated by using a lymph vessel phantom. The lymph vessels of mice were then visualized using the selected contrast agents: indocyanine green (ICG) and gold nanorods (AuNR). The attenuation of the PA imaging was −1.90 dB/mm, whereas that of the fluorescence imaging was −4.45 dB/mm. The results indicate the potential of identifying sentinel lymph nodes by using PA imaging with these contrast agents.

本文言語	English
ページ（範囲）	39-48
ページ数	10
ジャーナル	Photoacoustics
巻	9
DOI	https://doi.org/10.1016/j.pacs.2018.01.001
出版ステータス	Published - 2018 3月

ASJC Scopus subject areas

原子分子物理学および光学
放射線学、核医学およびイメージング

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1016/j.pacs.2018.01.001

他のファイルとリンク

引用スタイル

@article{313a3cefd0ce4292865e20c4e3212764,

title = "Visualization of murine lymph vessels using photoacoustic imaging with contrast agents",

abstract = "Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of scattered light was evaluated by using a lymph vessel phantom. The lymph vessels of mice were then visualized using the selected contrast agents: indocyanine green (ICG) and gold nanorods (AuNR). The attenuation of the PA imaging was −1.90 dB/mm, whereas that of the fluorescence imaging was −4.45 dB/mm. The results indicate the potential of identifying sentinel lymph nodes by using PA imaging with these contrast agents.",

keywords = "3D-real-time imaging systems, Contrast agents, Light wavelength dependence of photoacoustic signals, Lymph vessels, Photoacoustic tomography, Ultrasonic transducer arrays",

author = "Ryo Nagaoka and Takuya Tabata and Shin Yoshizawa and Umemura, {Shin ichiro} and Yoshifumi Saijo",

note = "Funding Information: This work was funded by the ImPACT Program of the Council for Science, Technology and Innovation (Cabinet Office, Government of Japan) . This work was supported a JSPS Grant-in-Aid for Young Scientists (Start-up) 16H066190 . Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2018",

month = mar,

doi = "10.1016/j.pacs.2018.01.001",

language = "English",

volume = "9",

pages = "39--48",

journal = "Photoacoustics",

issn = "2213-5979",

publisher = "Elsevier GmbH",

}

TY - JOUR

T1 - Visualization of murine lymph vessels using photoacoustic imaging with contrast agents

AU - Nagaoka, Ryo

AU - Tabata, Takuya

AU - Yoshizawa, Shin

AU - Umemura, Shin ichiro

AU - Saijo, Yoshifumi

N1 - Funding Information: This work was funded by the ImPACT Program of the Council for Science, Technology and Innovation (Cabinet Office, Government of Japan) . This work was supported a JSPS Grant-in-Aid for Young Scientists (Start-up) 16H066190 . Publisher Copyright: © 2018 The Authors

PY - 2018/3

Y1 - 2018/3

N2 - Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of scattered light was evaluated by using a lymph vessel phantom. The lymph vessels of mice were then visualized using the selected contrast agents: indocyanine green (ICG) and gold nanorods (AuNR). The attenuation of the PA imaging was −1.90 dB/mm, whereas that of the fluorescence imaging was −4.45 dB/mm. The results indicate the potential of identifying sentinel lymph nodes by using PA imaging with these contrast agents.

AB - Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of scattered light was evaluated by using a lymph vessel phantom. The lymph vessels of mice were then visualized using the selected contrast agents: indocyanine green (ICG) and gold nanorods (AuNR). The attenuation of the PA imaging was −1.90 dB/mm, whereas that of the fluorescence imaging was −4.45 dB/mm. The results indicate the potential of identifying sentinel lymph nodes by using PA imaging with these contrast agents.

KW - 3D-real-time imaging systems

KW - Contrast agents

KW - Light wavelength dependence of photoacoustic signals

KW - Lymph vessels

KW - Photoacoustic tomography

KW - Ultrasonic transducer arrays

UR - http://www.scopus.com/inward/record.url?scp=85041461306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041461306&partnerID=8YFLogxK

U2 - 10.1016/j.pacs.2018.01.001

DO - 10.1016/j.pacs.2018.01.001

M3 - Article

AN - SCOPUS:85041461306

SN - 2213-5979

VL - 9

SP - 39

EP - 48

JO - Photoacoustics

JF - Photoacoustics

ER -

Visualization of murine lymph vessels using photoacoustic imaging with contrast agents

抄録

ASJC Scopus subject areas

UN SDG

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル